Advanced Drug Delivery Technologies

How It Works:

Active ingredients are absorbed directly into the bloodstream through the highly vascular sublingual mucosa, avoiding degradation in the digestive system.

Key Benefits:

• Rapid onset (15-30 minutes vs 60-90 for oral)
• Higher bioavailability (60-70% vs 20-40%)
• Avoids first-pass liver metabolism
• Lower dose required for same effect
• No GI side effects

Best For:

Ingredients degraded by stomach acid, substances heavily metabolized by liver, rapid action needed

How It Works:

Specialized formulation with super-disintegrants causes tablet to break down in <30 seconds on the tongue, allowing immediate absorption.

Key Benefits:

• No water needed (convenient anytime, anywhere)
• Fast disintegration and absorption
• Improved compliance (elderly, children, dysphagia)
• Pleasant taste with proper masking
• Discreet administration

Used In:

Prescription drugs like Zofran ODT, Claritin RediTabs – now available in premium supplements

How It Works:

Active ingredients encased in tiny lipid spheres (50-200nm) that mimic cell membranes, protecting through digestion and fusing with intestinal cells for direct delivery.

Key Benefits:

• Protection from stomach acid and enzymes
• Enhanced absorption (2-4x standard formulations)
• Targeted cellular delivery
• Sustained release of actives
• Improved tolerability

True vs Fake Liposomes:

We verify with particle size analysis and electron microscopy – not just mixing with lecithin

Applications:

Vitamin C, Glutathione, Curcumin, CoQ10, Resveratrol

How It Works:

Semi-permeable membrane allows water in, creating osmotic pressure that forces drug out through laser-drilled orifice at constant rate – pH independent.

Key Benefits:

• Steady blood levels (no peaks/valleys)
• Once-daily dosing convenience
• Reduced side effects from peaks
• Predictable, engineered release rate
• Improved efficacy

Pharmaceutical Examples:

Concerta (ADHD), Glucotrol XL (diabetes) – proven technology now in premium supplements

How It Works:

Reducing particle size to nanoscale dramatically increases surface area, enabling faster dissolution and enhanced penetration across biological barriers.

Key Benefits:

• Increased surface area = faster dissolution
• Enhanced absorption and bioavailability
• Improved penetration (skin, cells)
• Transparent formulations (cosmetics)
• Elegant textures and feel

Applications:

Supplements: Poorly soluble ingredients (CoQ10, curcumin)
Cosmetics: Transparent zinc sunscreens, active delivery

How It Works:

Array of microscopic needles (<1mm) painlessly penetrate stratum corneum, dissolving to release payload directly into viable epidermis/dermis.

Key Benefits:

• Painless (too short to reach nerves)
• Minimally invasive (microscopic)
• Can deliver large molecules (peptides, proteins)
• Self-administered (no clinic visit)
• No sharps waste or needle phobia

Applications:

Pharma: Vaccines, insulin alternatives
Cosmetics: Peptides, growth factors, HA
Our Pipeline: Peptide microneedle system in development